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Purpose: The purpose of the study was to identify the effect of stress on the relations between emotional intelligence and burnout among nursing college students. Methods: The study is a cross-sectional survey and the participants were 363 students attending a nursing college located in Seoul. Data were collected by convenience sampling using self-reported questionnaires that consisted of general characteristics, emotional intelligence, perceived stress and burnout. Data were analyzed by descriptive statistics, t-test, ANOVA, correlation, and multiple regression. Results: Findings of the multiple regression were as follows. First, emotional intelligence had a significant negative-effect on stress. Second, emotional intelligence had a significant negative- effect on burnout. Third, stress had a significant positive-effect on burnout and had a mediating effect on the relationship between emotional intelligence and burnout. Conclusion: Results of the study suggest that as a way to reduce nursing college students' stress and burnout, programs which help improve nursing college students' emotional intelligence should be developed and implemented.