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Purpose: The purpose of this study was to investigate the effects of job stress and support from supervisors on depression of care givers in elderly care facilities. Methods: Subjects were 191 care givers working in elderly care facilities in K-Province in Korea. Data were collected from self-administered questionnaires. Descriptive statistics, x2 test, t-test, F-test, Pearson's and Spearman's correlation coefficients, and hierarchical multiple logistic regression with dummy variables were used for statistical analysis of data. Results: Job stress measured with Korean Occupational Stress Scale was 56.16±5.88. Emotional and instrumental support from supervisors were 37.05±7.30 and 32.39±7.34, respectively. After controlling for general characteristics, job stress was significantly related to depression (OR: 1.07, 95% CI: 1.01~1.14). However, job stress became non-significant in the model that included instrumental support from supervisors. Not emotional but instrumental support from supervisors was significantly related to depression of care givers (OR: 0.93, 95% CI: 0.88~0.99). Conclusion: Results of this study suggest that job stress has negative effects and instrumental support from supervisors has protective effects on depression of care givers in elderly care facilities. Therefore, measures to increase instrumental support by supervisors should be developed to improve psychological health of care givers in elderly care facilities.