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영어

Bee venom, also known as apitoxin, is a bitter colorless liquid, which has a quite stability in temperature. It has been used for many years in traditional therapy as relieve pain and treat inflammatory. The skin goes change due to aging by environmental factors, divided in to intrinsic and extrinsic. ultraviolet (UV), one of extrinsic factor, is known as a main inducer of skin aging. Especially, UVB reported that lead to DNA damage, sun burn, and ROS creation. In this study, researcher investigated that whether bee venom affects to aging manifestations, such as wrinkle, sagging, skin tone, and evenness. To evaluate efficacy on aging skin phenomena, clinical efficacy trials were conducted using Antera 3D, Robo skin analyzer CS50, KONG PC Camera, and spectrophotometer. Improvement of wrinkle, sagging, and skin evenness were assessed using ANTERA 3D. Robo skin analyzer CS50 and spectrophotometer assessed improvement of skin tone. KONG PC Camera used to measuring facial keratinized cell. Measurements were taken three times, namely, before application, immediately after treatment, and 1 week after treatment. Through cellular efficacy trials, using human dermal fibroblasts (HDFs), researchers verified that bee venom has protective effects on UVB induced gene expression of MMP1 and COL1A1, which known as extracellular matrix (ECM) regulated genes. In conclusion, bee venom improves UVB-induced cellular damage, including ECM regulated gene expression, and aged skin manifestations. These results suggest bee venom as a new, effective anti-aging cosmetic ingredient.