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This is a descriptive research to identify the factors affecting the adversity experienced by nurses and office workers. The research was conducted among 270 nurses at a general hospital and 192 office workers in the metropolitan area, and the collected data were analyzed using an SPSS 20.0 program. Statistically significant differences were found in emotional intelligence and the adversity quotient between nurses and office workers. Nurses had both variables at lower levels compared to office workers. Statistically significant correlation was found between the adversity quotient and emotional intelligence in each group. In each group, emotional intelligence significantly affected statistically the adversity quotient. It accounted for 19.0% for nurses and 26.0% for office workers. On the basis of these results, it is necessary to develop and employ a program to improve emotional intelligence, which was found to affect the level of adversity quotient, and develop an intervention strategy to raise the adversity quotient, particularly a customized intervention strategy for nurses who had emotional intelligence and adversity quotient at lower levels compared to office workers. The objective is to help them cope efficiently with their changing job environment and to improve the quality of each work service, the nurses’ and office workers’ job satisfaction, and their quality of life.