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연구논문 : 원보

제 2형 당뇨병 환자의 유방암 발생 위험 및 사망률에 대한 메트포민의 영향 : 체계적 문헌고찰 및 메타분석

원문정보

Effects of Metformin on Breast Cancer Risk and Mortality in Type 2 Diabetes Mellitus : A Systematic Review and Meta-analysis

천부순

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

Background: The protective effect of metformin against breast cancer is inconclusive. Objective: To evaluate the effect of metformin on breast cancer risk and mortality in patients with type 2 diabetes. Method: A comprehensive literature search was performed for pertinent articles published prior to June 30, 2014, using PubMed and EMBASE. Study heterogeneity was estimated with I2 statistic. The data from the included studies were pooled and weighted by random-effects model. The quality of each included study was assessed on the basis of the 9-star Newcastle-Ottawa Scale and publication bias was evaluated by visual inspection of a funnel plot. Results: Ten studies were included in the meta-analysis of the association of metformin and breast cancer risk. By synthesizing the data from the studies, the pooled odds ratio (OR) was 0.72 (95% CI: 0.59, 0.87) (p = 0.0005). Three cohort studies were included for meta-analysis of the association between metformin and breast cancer- related mortality. Metformin was associated with a significant decrease in mortality (Risk ratio: 0.68; 95% CI: 0.51, 0.90, p = 0.007). Conclusion: The present metaanalysis suggests that metformin appears to be associated with a lower risk of breast cancer incidence and mortality in patients with type 2 diabetes.

목차

ABSTRACT
 Introduction
 Methods
  Data sources and searches
  Study selection
  Data extraction and quality assessment
  Data synthesis and analysis
 Results
  The effect of metformin therapy on breast cancer risk
  The effect of metformin use on breast cancer-relatedmortality
 Discussion
 Conclusion
 Acknowledgement
 References

저자정보

  • 천부순 Pusoon Chun. 인제대학교 약학대학

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