원문정보
초록
영어
Brain-derived neurotrophic factor (BDNF) and its receptors tyrosine ki-nase B (trkB), and cyclic adenosine monophosphate response element binding protein (CREB) have been suggested as the neurobiological risk factors causing depressive disorder. Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the pathogenesis of depression. We in-vestigated the effect of treadmill exercise on social interaction in rela-tion with BDNF and 5-HT expressions following stress in rats. Stress was induced by applying inescapable 0.2 mA electric foot shock to the rats for 7 days. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 4 weeks. Social interaction test and western blot for BDNF, TrkB, pCREB, and 5-HT1A in the hippo-campus were performed. The results indicate that the spend time with unfamiliar partner was decreased by stress, in contrast, treadmill exer-cise increased the spending time in the stress-induced rats. Expres-sions of BDNF, TrkB, and pCREB were decreased by stress, in contrast, treadmill exercise enhanced expressions of BDNF, TrkB, and pCREB in the stress-induced rats. In addition, 5-HT1A receptor expression was de-creased by stress, in contrast, treadmill exercise enhanced 5-HT1A ex-pression in the stress-induced rats. In the present study, treadmill exer-cise alleviated stress-induced social interaction impairment through enhancing hippocampal plasticity and serotonergic function in the hip-pocampus. These effects of treadmill exercise are achieved through 5-HT1A receptor activation.
목차
INTRODUCTION
MATERIALS AND METHODS
Animals and treatments
Induction of stress
Exercise protocol
Social interaction test
Western blot for BDNF, TrkB, pCREB, and 5-HT
Data analysis
RESULTS
Effect of treadmill exercise on social interaction
Effect of treadmill exercise on BDNF and TrkB expressions in hippocampus
Effect of treadmill exercise on pCREB expression in hippocampus
Effect of treadmill exercise on 5-HT1A expression in hippocampus
DISCUSSION
REFERENCES