earticle

영어

Since driving under the influence of drugs(DUID) is just as dangerous as drink-driving, many countries regulate DUID by law. However risk perception of Korean people for drugged driving is still poor, the law against using drugs while driving is not established yet in detail. Oral fluid is non-invasive and easyto- use, and there is the good correlation between oral fluid and blood levels, the use of oral fluid as specimen for drug testing in DUID is available worldwide. In this study drug analysis in oral fluids and its application for drug testing in DUID were investigated. Drug lists which should be tested and various factors to be considered in oral fluid testing were researched. As the results, even though the drug lists prohibited in DUID were somewhat different in countries, the controlled drugs(legal and illegal drugs) were included in common for their lists. For methamphetamine and cannabis are most abused drugs in Korea, these drugs should be included firstly, and opiates, cocaine, benzodiazepines must to include to the DUID drug lists. Besides of controlled drugs, antihistamines and antidepressants as non-controlled drugs need to include to the lists. When oral fluid testing is applied to DUID, various factors have to be considered, i.e. specimen collection, specimen stability, chain of custody, scientific reliability, interpretation of test results and assessing likelihood of impairment. Laboratories have to establish analytical methods for drugs related to DUID in oral fluids and all methods should be validated with proper parameters to assure accuracy and reliability.