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초록
영어
Novel 2'(β)-fluoro-3'(α)-hydroxy-threose nucleosides (iso-FMAU) as antiviral agents were designed and racemically synthesized from Solketal. Condensation successfully proceeded from a glycosyl donor 9 under Vorbrüggen conditions yielded the nucleoside analogues. Ammonolysis and hydrolysis of isopropylidene protection group gave the desired nucleoside analogues 12, 15, 18, and 19. The antiviral activities of the synthesized compounds were evaluated against the HIV-1, HSV-1, HSV-2 and HCMV. Compound 12 displayed some anti-HCMV activity (EC50=24.7 μg/ml) without exhibiting any cytotoxicity up to 100 μM.
목차
Abstract
1. Introduction
2. Experimental Section
3. Results and Discussion
4. Conclusion
References
1. Introduction
2. Experimental Section
3. Results and Discussion
4. Conclusion
References
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저자정보
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