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Objectives: This thesis intends to find out the extent of drinking problem which is caused by students' psychosocial stress, expected alcohol effects and problem drinker drinking as well as the influence of each factor. Methods: This study was conducted from September 1, 2014 to October 31, 2014 with the target of 466 students (66.6%), who are currently drinking, out of 700 students over the age of 16 and enrolled in 36 universities located in the whole country. This data were analyzed using the program SPSS21. Results: Age, gender, and the school district that showed significant differences in drinking problem compared to other general characteristics played the role of control variables. It was found that psychosocial stress does not affect the drinking problem. The self-reward and human-relation factors included in the expected drinking effect were revealed to influence significantly on the problem and the life and health related factors included in the reason of drinking refrain were also turned out to have significant effect on that problem. The degree of F is 15.665 and the degree of explanatory is 23.6%. Conclusions: Problem drinker in college and enhance the culture and health education policy is necessary to reduce college student drinking effects expected.