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Objectives: The purpose of this study was to examine the effects that the self-efficacy, self-elasticity, and major satisfaction of students majoring in dental hygiene would have on the adaptation to the campus life. Methods: The total 396 students were surveyed who majored in dental hygiene in universities located at Gyeongbuk and Gyeongnam from October 15, 2013 to October 30. The collected data were analyzed by using the SPSS 17.0 program, along with the One-Way ANOVA, correlation analysis, and multi-regression analysis. Results: The ‘aptitude and interest’ were found to be greatest factor among the motive for application among the factors of self-efficacy, self-elasticity, and major satisfaction of students, depending on general characteristics. The results of correlation analysis showed that the self-elasticity had a correlation of 0.741 and the adaptation to the study had a correlation of 0.420 in the self-efficacy, while the individual emotional adaptation, adaptation to university environment, and adaptation to the study had a correlation as high as over 0.4 in the self-elasticity(p<0.05). In addition, it was found that the adaptation to the campus life increased proportionally to the self-elasticity and major satisfaction (p<0.05). Conclusions: To increase the campus life adaptation of students majoring in dental hygiene, it is considered necessary to explore the measures that can improve the self -elasticity and overall major satisfaction.