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Background: The purpose of this study was conducted to investigate the effects of Push-up plus exercise with kinesio taping on the pain and shoulder motor function in patient with shoulder myofacial pain syndrome. Methods: The patients with myofacial pain syndrome were randomly divided 2 groups. kinesio taping group (n=20) was taken physical therapy program and kinesio taping. Push-up plus exercise with taping group (n=22) was taken physical therapy and kinesio taping with Push-up plus exercise. The kinesio taping applied on upper trapezius and levator scapulae. The Push-up plus exercise performed in standing position and qudripad position during 10 seconds on 15 time, 3 set per each positions. We mearsured the pain degree using PPT, VAS, MPSSI and shoulder motor function using CSA before and after experiment. The significant test of PPT, VAS, MPSSI, CSA according to applying the kinesio taping and Push-up plus exercise between groups used ANCOVA. Results: In the result following analysis, there was significance on PPT (F=7.378, p=.016), VAS (F=13.071, p=.031), CSA (F=5.302, p=.026) between kinesio taping group and Push-up plus exercise with tapping group. Then, Push-up plus exercise with kinesio taping group has significance on the PPT, VAS, CSA in patients with myofacial pain syndrome. Conclusions: It may suggest that kinesio taping combined with Push-up plus exercise will be helpful of the pain and shoulder function improvement in the patients with myofacial pain syndrome.