원문정보
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초록
영어
Novel 2'(β)-methyl-5'-deoxyapiose purine phosphonic acid analogues were designed and synthesized from 2- propanone- 1,3-diacetate. Condensation successfully proceeded from a glycosyl donor 9 under Vorbrüggen conditions. Condensation of aldehyde 14 with Wittig reagent [(diethoxyphosphinyl)methylidene] triphenylphosphorane gave the desired nucleoside phosphonate analogues 15. Ammonolysis and hydrolysis of phosphonates gave the nucleoside phosphonic acid analogue 17 and 19. The synthesized nucleoside analogues were subjected to antiviral screening against HIV-1. The adenine analogue 19 exhibited weak in vitro activities against HIV-1.
목차
Abstract
1. Introduction
2. Experimental Section
3. Results and Discussion
Conclusion
Acknowledgment
References
1. Introduction
2. Experimental Section
3. Results and Discussion
Conclusion
Acknowledgment
References
저자정보
참고문헌
자료제공 : 네이버학술정보