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영어

This study was carried out to investigate the antioxidative, anti-inflammatory and antimicrobial activities of Evodia officinalis extracts for cosmetic applications. The DPPH radical scavenging activity and nitrate scavenging activity of the extract (400 ug/ml) of Evodia officinalis were 91.02 and 54%, respectively. DPPH radical scavenging activity of these extracts were higher than of BHT (standard antioxidant). The inhibition effect of the extracts on ROS production was examined in H2O2-treated HaCaT cells. ROS production was significantly inhibited by the extracts of Evodia officinalis (27.5%). These inhibition effects were increased in a dose-dependent manner. Protective effect of extracts on HaCaT cells against H2O2, rotenone, and paraquat were investigated. Evodia officinalis showed protective effect against cell death of HaCaT cell induced by H2O2, rotenone, and paraquat significantly. Anti-inflammatory effect by inhibition of NO production was examined in RAW264.7 cell. Experimental results show that the NO generation is suppressed in a concentration-dependent manner These Evodia officinalis extracts were tested against Staphylococcus. epidermidis, Staphylococcus aureus, Pityrosporum ovale and along with Propionibacterium acnes, Malassezia furfur and Candida albicans which causes skin inflammation. Paper disc assay and MIC tests were carried out the various concentrations of extracts. The extracts of Evodia officinalisA displayed effective growth inhibition against S. epidermidis, P. ovale, M. furfur, with MIC value S. epidermidis (25 ㎍/㎖) P. acnes (12.5 ㎍/㎖), P. ovale (50 ㎍/㎖), M. furfur (50 ㎍/㎖). The overall results of this study indicate that the Evodia officinalis have the possibility to develop as cosmetic sources for skin anti-oxidant, skin anti-aging and treatment of skin-related diseases.