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Purpose: This study aimed to confirm the effects of a simulation-based program on knowledge andclinical performance in the post-operative management of emergency patients. Methods: This was a pre- and post-research design with a nonequivalent control group and randomlysampled 29 experimental and control groups, respectively from nursing department juniors for 4 weeksfrom September of 2014. The experimental group received lectures, team study, team simulation, anddebriefing in post-operative management of simulation-based emergency patients and control groupconducted in the traditional lecture- type setting. Educational learning effects were measured by usingthe knowledge and clinical performance measurement tools of 15 and 20 items, respectively. Data wereanalyzed by using the SPSS program, including frequency, ratio, and results from the Chi-square test,Fisher's exact test, Kolmogorov-Smirnov test, t-test. Results: Our research results indicate that, the experimental group showed significantly higherknowledge and clinical performance score compared with the control group. Conclusion: We confirmed that education on post-operative management of simulation-based emergency patients was an effective educational method to improve the knowledge and clinical performance ofnursing students.