earticle

영어

Atopic dermatitis(AD) is chronic pruritic inflammatory skin disease. Patients with severe or persistent AD and their families suffer from significant impairment in their quality of life. AD places a heavy economic burden not only on patients and their families, but also on society in general. AD ha s been related inflammation and oxidative stress. immunological abnormalities is causing more severe AD lesion. HRW(Hydrogen reduced water) have antioxidant properties, and can exert anti-inflammatory effects. The purpose of this study was to determine the drinking effect of the HRW with the properties of high pH and low ORP in mice induced AD skin lesions. Mice were sensitized using 2,4-dinitrochlorobenzene(DNCB) to cause AD-like skin lesions in NC/Nga mice, and taken Hydrogen reduced water(HRW group) or purified water(PW group). We found that Interlukin(IL)-1β, IL-2, IL-4, IL-5, IL-10, IL-12(p70), Granulocyte macrophage-colony stimulating factor (GM-CSF), Interferon-gamma (INF-r), and Tumor necrosis factor –alpha (TNF-a) werw less in the HRW group compared to the PW group. These results suggest that regular drinking HRW with the properties of high pH and low ORP has a positive effect on AD skin lesions.