원문정보
초록
영어
Protein structure prediction has matured over the past few years to the point that even fully automated methods can provide reasonably accurate three-dimensional models of protein structures. However, until now it has not been possible to develop programs able to perform as well as human experts, who are still capable of systematically producing better models than automated servers. In this paper, we review and compare two recently developed and publicly available software packages, LOMETS and I-TASSER, for predicting protein structure in comparison with the commercial software package (Hyper Chem Release 8.0). These two software packages share some common features and also have some fundamental difference. Based on our experience, I-TASSER is more accurate in predicting protein structure. In contrast, LOMETS shows less performance than I-TASSER.
목차
1. Introduction
2. Background
3. Software for Comparison
3.1. First Academic Software Package: LOMETS
3.2. Second Academic Software Package: I-TASSER
4. Software Results of Comparison
4.1. Data Used for Comparison
4.2. Software Results and Performance Evaluation
5. Conclusions and Discussion
References