earticle

영어

Activity-induced muscle injury and dysfunction have been identified as key components of musculoskeletal injuries. These injuries often occur following eccentric contractions, when the muscle is under tension and stretched by a force that is greater than the force generated by the muscle. Many daily activities require muscles to perform eccentric contractions, including walking (or running) downhill or down stairs, lowering heavy objects, and landing from a jump. Injuries often occur when these activities are performed at high intensity or for prolonged periods of time. General features of eccentric-induced muscle injury are well documented and include disruption of intracellular muscle structure, prolonged muscle weakness and dysfunction, a delayed-on-set muscle soreness, and inflammation. Several weeks are required for the affected tissue to fully regenerate and recover from eccentric-in-duced muscle injury. Possible mechanisms responsible for eccentric-in-duced muscle injury are activation impairment and structural disruption of the sarcomere. These two factors seem to be the main sources of ec-centric-induced muscle injury. Rather than being separate mechanisms they may be complimentary and interact with each other. Therefore, in this review we will focus on the two main cellular mechanism of muscle cell injury following accustomed eccentric contraction.