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Men have always been curious about human behavior and brain w hich controls the behavior. The supposition that brain could control human behavior is not just a supposition anymore, and brain science is continuously developing to prove that supposition. With the develo pment, men are now able to take photos of brain structure and brai n response. Cognition brain science researches men’s sensory system, motor nerve system, concentration, memory, linguistic ability, cognitive abil ity, emotion and perception ability that differs by brain structure and function. The advancement of brain technology such as PET scan, f MRI, MRI influenced research on brain. Before this technological adv ancement, scientists relied on animal experiment or computer modeli ng for brain study. The use of neuroscience evidence is on the rise, as indicated by a doubling of cases in the United States. Accordingly, with a focus on Louisiana, this comment show the burgeoning discipline of law an d neuroscience by analyzing the multifaceted difficulties of offering neuroscience evidence for purpose of claims of insanity to avoid cri minal responsibility. However, the rapid advancements in neuroscience, it is unlikely that cognitive neuroscience can do what Louisiana law necessitates in providing criminal insanity. Therefore, given the admissibility of neuroscience evidence resulting from Louisiana’ rigorous legal stand ards, criminal sentencing is the legal context most likely to experie nce new form of neuroscience evidence in Louisiana.