earticle

영어

5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), commonly called Foxy or Foxy methoxy is one of the novel synthetic designer drugs derived from tryptamine. It has hallucinogenic properties similar to other tryptamines, euphoria, empathy, a sense of intimacy to others, and emotional distress. It also causes dilated pupils, visual and auditory distortion, nausea, vomiting and diarrhea in its abusers. 5-MeO-DIPT has been abused since the 1990s. Due to its recreational abuse, many countries including several European countries, Japan and USA have banned the use of this drug since 1999. Korea Government started the control of 5-MeO-DIPT since 2006. Even though there were a few cases of its identification in seized tablets in Korea, there was no case of 5-MeO-DIPT user. Recently, we encountered two male abusers who took a pill contained 5-MeO-DIPT which was bought from Japan. From their urine samples, we confirmed 5-Meo-DIPT and its metabolites, 5-hydroxy-N,N-diisopropyltryptamine (5-OH-DIPT), 6-hydroxy-5- methoxy?N,N-diisopropyl tryptamine (6-OH-5-MeO-DIPT), 5-methoxy- N-isopropyltryptamine (5-MeO-NIPT). In order to identify 5- MeO-DIPT and its metabolites, the urine specimens were extracted in Automatic Solid-phased extraction with a mixed-mode cation exchange cartridge. For identification, they were derivatized by MSTFA and analyzed by using Gas chromatography/mass spectrometry with full scan mode. As a result, we confirmed 5-MeO-DIPT and its metabolites, 5-OH-DIPT, 6-OH-5-MeO -DIPT, 5-MeO-NIPT in the two abusers’urine. It was the first case that was detected 5-MeO-DIPT and its metabolites from abusers’urine in Korea.