원문정보
초록
영어
Aimp1 is known as a multifunctional cytokine in various cellular events. Recent study showed Aimp1 is localized in glandular epithelial, endothelial, and stromal cells in functionalis and basalis layers of the endometrium. However, the regulatory mechanism of Aimp1 in the uterus remains unknown. In the present study, we found that Aimp1 is expressed in the mouse uterus. Aimp1 transcripts were decreased at diestrus stage. However, the level of Aimp1 protein was significantly increased in the luminal epithelium in the uterine endometrium at the estrus stage during the estrous cycle. In addition, we found that the treatment of estrogen increased the expression of Aimp1 in the uterus. The treatment of estrogen increased Aimp1 expression in the uterus of ovarectomized mice. We identified one estrogen receptor binding element (ERE) on the mouse Aimp1 promoter. The activity of Aimp1 promoter was increased with estrogen treatment. Our findings indicate that Aimp1 might act as an important regulator to remodel the uterine endometrium and its expression might be regulated by estrogen during the estrous cycle. This will give us better understanding the dynamic change of uterine remodeling during the estrous cycle.