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Objectives: This study examines the mediation role of drinking motives between alcohol drinking expectancies and employee drinking behavior at the workplace. Methods: The participants were 621 Korean workers who working for small and medium business in Daegu and Gyeonsangbukdo. This study tested mediating effects of employee drinking motives between alcohol expectancies and drinking behavior at workplace. Collected data were analyzed by SPSS 20.0. Results: Both positive and negative alcohol drinking expectancy significantly affected on alcohol drinking behavior and alcohol drinking motives. There was a significant mediating effect on alcohol drinking behavior of positive alcohol drinking expectancy with enhancement motive, coping motive, and social motive. Finally, the mediating effect of alcohol drinking motive on the relationship between negative alcohol drinking expectancy and alcohol drinking behavior of worker did not have a significantly influence. Conclusion: This result suggested that drinking motives would be significant role as antecedents factor on employee alcohol drinking behavior at the workplace. In conclusion, the present study provided some theoretical and practical implications in addition to limitations.