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Objectives: This study examined the relationship between drinking level and nicotine dependence to provide useful information for health promotion programs. Methods: The participants were 308 university students who were using alcohol and cigarettes concurrently.Drinkinglevelwasmeasured by the AUDIT and nicotine dependence was measured by the FTND. The statistical methods used for data analysis were descriptive statistics, t-test, F-test, correlation analysis, and multiple linear regression analysis. Results: First, drinking level, nicotine dependence, and stress are significantly highly associated. Specifically, nicotine dependence and stress were correlated with drinking level. Second, multiple linear regression analysis showed that drinking level had a strong causality on nicotine dependence. Conclusion: This study found that drinking level had a greater effect on nicotine dependence. Alcohol drinking is likely to be the cause of smoking, and alcohol prevention will be more important than smoking in health promotion programs for university students.