원문정보
초록
영어
Schizophrenia is a serious psychiatric disorder with several symptoms including cognitive dysfunction. Although the causes of schizophrenia are still unclear, there is a strong suspicion that the abnormality in N- methyl-D-aspartate (NMDA) receptor may contribute to schizophrenia symptoms. In the present study, the effect of treadmill exercise on the NMDA receptor expression was evaluated using MK-801-induced schizophrenia mice. Immunohistochemistry for expressions of NMDA receptor tyrosine hydroxylase (TH) was conducted. Western blot for brain-derived neurotrophic factor (BDNF) was also performed. In the present results, the mice in the MK-801-treated group displayed re-duced NMDA receptor expression. Enhanced TH expression and sup-pressed BDNF expression were also observed in the MK-801-treated mice. Treadmill exercise improved NMDA receptor expression in the MK-801-induced schizophrenia mice. Treadmill exercise also suppressed TH expression and enhanced BDNF expression in the MK-801-in-duced schizophrenia mice. The present study showed that down-regu-lation of NMDA receptor demonstrated schizophrenia-like parameters, meanwhile treadmill running improved schizophrenia-related parame-ters through enhancing NMDA receptor expression.
목차
INTRODUCTION
MATERIALS AND METHODS
Materialsimmunohistochemistrydescribed
Experimental animals and design
Exercise protocol
Tissue preparation
NMDA receptors immunohistochemistry
Tyrosine hydroxylase immunohistochemistry
Western blot for BDNF expression
RESULTS
Effect of treadmill exercise on the number of NMDA receptor-positive cells in the dentate gyrus.
Effect of treadmill exercise on the number of NMDA receptor-positive cells in the prefrontal cortex
Effect of treadmill exercise on the TH expression in the striatum
Effects of treadmill exercise on the BDNF expression in the hippocampus
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES