Original Article

Effects of endurance exercise on expressions of glial fibrillary acidic protein and myelin basic protein in developing rats with maternal infection-induced cerebral palsy


Kijeong Kim, Mal-Soon Shin, Han-Sam Cho, Young-Pyo Kim

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Periventricular leukomalacia (PVL) is a common white matter lesion af-fecting the neonatal brain. PVL is closely associated with cerebral palsy (CP) and characterized by increase in the number of astrocytes, which can be detected by positivity for glial fibrillary acidic protein (GFAP). Change in myelin basic protein (MBP) is an early sign of white matter abnormality. Maternal or placental infection can damage the neonatal brain. In the present study, we investigated the effects of treadmill walk-ing exercise on GFAP and MBP expressions in rats with maternal lipo-polysaccharide (LPS)-induced PVL. Immunohistochemistry was per-formed for the detection of GFAP and MBP. The present results showed that intracervical maternal LPS injection during pregnancy increased GFAP expression in the striatum and decreased MBP expression in the corpus callosum of rats. The results also showed that treadmill walking exercise suppressed GFAP expression and enhanced MBP expression in the brains of rats with maternal LPS-induced PVL. The present study revealed that treadmill walking exercise is effective for the suppressing astrogliosis and hypomyelination associated with PVL. Here in this study, we showed that treadmill walking exercise may be effective therapeu-tic strategy for alleviating the detrimental effects of CP.


  Animals and treatments
  Exercise protocol
  Tissue preparation
  GFAP and MBP immunohistochemistry
  Data analysis
  Effects of treadmill walking exercise on body weight in rats with maternal endotoxin-induced PVL
  Effect of treadmill walking exercise on GFAP expression in the striatum of rats with maternal endotoxin-induced PVL
  Effect of treadmill walking exercise on MBP expression in the corpus callosum of rats with maternal endotoxin-induced PVL


  • Kijeong Kim School of Exercise and Sport Science, University of Ulsan, Ulsan, Korea
  • Mal-Soon Shin Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
  • Han-Sam Cho Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
  • Young-Pyo Kim Faculty of Exercise & Sports Science, Jeju National University, Jeju, Korea


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