earticle

영어

Recent studies showed association between diseases and TLR6 poly-morphisms. To investigate whether TLR6 polymorphisms are associated with the development of ischemic stroke, four single nucleotide poly-morphisms (SNPs) of the TLR6 gene (rs1039559, rs3821985, rs3775073, and rs5743818) were analyzed in 120 patients with ischemic stroke (IS) and 278 control subjects. All ischemic stroke patients were classified into clinical subgroups according to NHISS and MBI. SNPStats was used to obtain odds ratios (ORs), 95% confidence intervals (CIs), and P values. Multiple logistic regression models (codominant1, codominant2, dominant, recessive, and log-additive) were performed to analyze the genetic data. Two SNPs (rs3821985 and rs3775073) of the TLR6 gene were associated with the NHISS in ischemic stroke patients (P<0.05). Also, three SNPs (rs1039559, rs3821985, and rs3775073) showed associ-ation with MBI in ischemic stroke patients (P<0.05). These results sug-gest that SNPs of TLR6 (rs1039559, rs3821985, and rs3775073) may be af-fect the disease characteristics of stroke, such as NIHSS and MBI.