원문정보
초록
영어
Embryonic genome activation (EGA) is a highly complex phenomenon that is controlled at various levels. New studies have ascertained some molecular mechanisms that control EGA in several species; it is apparent that these same mechanisms regulate EGA in all species. Protein phosphorylation, DNA methylation and histone modification regulate transcriptional activities, and mechanisms such as ubiquitination, SUMOylation and microRNAs post-transcriptionally regulate development. Each of these regulations is highly dynamic in the early embryo. A better understanding of these regulatory strategies can provide the possibility to improve the reproductive properties in mammals such as pigs, to develop methods of generating high-quality embryos in vitro, and to find markers for selecting developmentally competent embryos.
목차
INTRODUCTION
GENERAL TRANSCRIPTION FACTORS
RNA POLYMERASE II CTD
EMBRYONIC GENOME ACTIVATION
EGA and Maternal mRNA Degradation
CTD Phosphorylation and EGA
RNA POLYMERASE II CTD KINASE
P-TEFb
TFIIH
RNA POLYMERASE CTD PHOSPHATASE
CONCLUSIONS AND PERSPECTIVES