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This paper presents the development of a virtual patient simulation by a 3D talking head and its use by pharmacy students as a training aid for patient consultation. The paper concentrates on the virtual patient modeling, its synthesis with a speech engine and facial expression interaction. The virtual patient model is developed in three stages: building a personalized 3D face model; animation of the face model; and speech driven face synthesis. The model is used in conjunction with a training artificial intelligence module that creates several scenarios in which the student oral interview ability is assessed. The final evaluation phase is a randomized controlled trial at three partner universities: The University of Newcastle, Monash University and Charles Stuart University. It shows the potential to revolutionize the way pharmacy students’ training is conducted.