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논문검색

Poster 29

Functional characterization of endoplasmic reticulum stress sensors in Arabidopsis thaliana

원문정보

Jae Yong Yoo, Wahyu Indra Fanata, Rikno Harmoko, Ki Seong Ko, Nirmal Kumar Ramasamy, Kyung Hwa Kim, Thiyagarajan Thulasinathan, Ryun Gyeong Kim, Sang Yeol Lee, Kyun Oh Lee

한국당과학회 한국당과학회 학술대회 2013 한국당과학회 하계학술대회 2013.08 pp.77-78
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Environmental or physiological influences that induce accumulation of unfolded proteins in the lumen of endoplasmic reticulum (ER) cause ER stress and activate signaling pathway called unfolded protein response (UPR). An ER-located transmembrane receptor protein kinase/ribonuclease called Ire1 plays an essential role in the UPR in yeasts and mammals. However, it has been unclear whether a similar mechanism is applicable to Arabidopsis. To elucidate the role of Arabidopsis IRE1, we performed functional analyses by isolating loss-of-function mutants of IRE1A and IRE1B. We found that a double mutant of Arabidopsis IRE1A and IRE1B (ire1a ire1b) is more sensitive to the ER stress inducer tunicamycin than the wild-type. ire1a ire1b result in a delayed induction of BiP3 that is well known ER chaperone by tunicamycin treatment, whereas induction of several other ER chaperones in ire1a ire1b was similar with that of WT. Our results indicate that IRE1A and IRE1B are implicated in unfolded protein response signaling in plants.

저자정보

  • Jae Yong Yoo Division of Applied Life Science and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju 660-701, Korea
  • Wahyu Indra Fanata Division of Applied Life Science and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju 660-701, Korea
  • Rikno Harmoko Division of Applied Life Science and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju 660-701, Korea
  • Ki Seong Ko Division of Applied Life Science and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju 660-701, Korea
  • Nirmal Kumar Ramasamy Division of Applied Life Science and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju 660-701, Korea
  • Kyung Hwa Kim Division of Applied Life Science and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju 660-701, Korea
  • Thiyagarajan Thulasinathan Division of Applied Life Science and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju 660-701, Korea
  • Ryun Gyeong Kim Division of Applied Life Science and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju 660-701, Korea
  • Sang Yeol Lee Division of Applied Life Science and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju 660-701, Korea
  • Kyun Oh Lee Division of Applied Life Science and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju 660-701, Korea

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