earticle

영어

Carbohydrates have been known to play biologically important roles such as cell adhension, cell recognition, fertilization and embryogenesis though interactions with proteins. Importantly, these biomolecular interactions are also involved in tumor metastasis and inflammation. In addition, some pathogens infect human though interactions between the pathogenic proteins and human glycans. For example, human influenza virus produce proteins that preferentially adhere to NeuNAcα2,6Gal residues on epithelial cells of the lungs and upper respiratory tract. Some of Helicobacter pyroli which express Leb binding adhesin (BabA) and sialyl Lex-binding adhesin (SabA) recognize the human gastric mucosa expressing these glycans. To detect pathogens as well as mammalian cells, various glycoconjugates, including Lea, Leb, H1, Lex and Ley, were synthesized.