earticle

영어

Pigmentation is the process of melanin synthesis by melanocytes within the skin and hair follicles. The melanin synthesized plays an important role in protecting the skin from the harmful effects of ultraviolet (UV) irradiation. However, excessive synthesis and uneven distribution of melanin can lead to esthetic problems. We synthesized several materials with and without kojic acids moiety which showed potent tyrosinase inhibitory activities. These molecules show good activity in antioxidant test. In some cases, treatment of melan-a cells with these compounds decrease in protein and m-RNA levels of tyrosinase along with tyrosine-rlated protein. These finding suggest that depigmenting materials is can be used as a potent whitening agent.