earticle

영어

Most cancer cells produce energy by glycolysis followed by fermentation in the cytosol, even though they exist in the presence of oxygen. But the research about cancer metastasis has been limited to hypoxia condition until now. Interestingly it was reported that O-GlcNAc modification on protein was significantly increased under hypoglycemic condition. O-GlcNAcylation is one of the post-translational protein modification and it appears to be involved in many different cellular activities. And it was thought that O-GlcNAcylation is also related with EMT. In our study, we want to examine whether hypoglycemic condition can induce cancer metastasis and it is related to increased O-GlcNAc modification or not. So we focused on EMT to visualize cancer metastasis. We found that the amount of several EMT marker were changed under hypoglycemic condition in cancer cell. And one of them was O-GlcNAcylated. These findings tell us that hypoglycemic condition can be closely connected with cancer metastasis via O-GlcNAclation. So we suggest possibilities that hypoglycemic condition induced EMT in cancer cell and it related with increased O-GlcNAc modification.