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Objectives: The main purpose of this study was to compare influencing factors ondepression between male and female students at the high school. Methods: The self-administered questionnaire survey was carried out on a convenience sample of 403 high school students. The data analysis procedure included frequency, χ2 test, t-test, ANOVA, Pearson correlation coefficients, and stepwise multiple regression using depression as the dependent variable. Results: There was a significant gender difference in depressive symptoms; the meandepression score of female students was higher than that of male students. Stepwisemultiple regression analysis for depression revealed that the most powerful predictors(34%) were powerlessness and self-esteem for male students. On the other hand, the factors such as self-esteem, mother's occupation, and family fucntion were the most significant predictors (50%) for female students. Conclusion: The necessity of an intervention considering gender difference in highschool students so as to prevent the occurrence of depression was suggested.