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초록
영어
Human P-gp is a protein responsible for the multidrug resistance (MDR) and causes failure of cancer chemotherapy. Till date no X-ray crystal structure is reported for this membrane protein, which hampers active research in the field. We performed homology modeling to develop three dimensional (3D) model of P-gp, and docking studies of the verapamil and curcumin have been performed to gain insight into the interaction mechanism between inhibitors and P-gp. It was identified that the inhibitors docked into the upper part of P-gp and interacted through the hydrophobic interactions.
목차
Abstract
1. Introduction
2. Experimental Section
2.1. Sequence Alignment and Homology Model
2.2. Docking of Inhibitors into P-gp Model
3. Results and Discussion
3.1. Analysis of Sequence Alignment and Model
3.2. Binding Mode Analysis
4. Conclusion
Acknowledgements
References
1. Introduction
2. Experimental Section
2.1. Sequence Alignment and Homology Model
2.2. Docking of Inhibitors into P-gp Model
3. Results and Discussion
3.1. Analysis of Sequence Alignment and Model
3.2. Binding Mode Analysis
4. Conclusion
Acknowledgements
References
저자정보
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자료제공 : 네이버학술정보