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purpose: This study aims to understand the relationship between stress in college life, vulnerability to depression, and smartphone overuse among undergraduate students majoring in public health. Methods: The subjects of the study were 320 students who were selected through convenience sampling from the department of emergency medical technology, physical therapy, and public health and administration attending G University in Gwangju. The study was carried out from October 22 to 26, 2012. For final analysis, 266 copies were used. Statistical analysis was done using SPSS WIN 12.0. Results: Excessive use of smartphones had a negative effect on stress in college life and vulnerability to depression. The stress of college life had an effect on students' sense of value, their friends of the same sex, and job. Depressive vulnerability had an effect on a students' dependency. Conclusion: For the prevention of smartphone overuse, programs to prevent college life stress and vulnerability to depression should be developed. Counselling programs for the groups should be made available to the students.