원문정보
초록
영어
The huge amount of biological information implies a great challenge for data analysis, particularly for combinatorial methods such as Multifactor Dimensionality Reduction. This method can be computationally intensive, especially when more than ten polymorphisms need to be evaluated. The Grid is a promising architecture for genomics problems providing high computing capabilities. In this paper, we describe a framework for supporting the MDR method on Grid environments. This framework helps biologists to automate the execution of multiple tests of gene-gene interactions detection. To evaluate the eciency of the proposed framework, we conduct experiments on the Grid5000. A Grid infrastructure distributed in nine sites around France, for research in large-scale parallel and distributed systems. compute-intensive
목차
1 Introduction
2 Multifactor Dimensionality Reduction method
3 Implementation details
3.1 Distributed formulation of the MDR method
3.2 Framework Architecture
4 Empirical experiments
5 Related works
6 Conclusion
Acknowledgements
References