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Dynamic Programming for Protein Sequence Alignment

초록

영어

Dynamic programming is a method for solving complex problems by breaking them down into simpler subproblems. This idea is very insightful for solving bioinformatics problems. Aligning distantly related protein sequences is a long-standing problem in bioinformatics and a key for successful protein structure prediction. A fast and valid algorithm can benefit the whole process of biology research. In this paper, we introduce an algorithm that given a certain evaluation function, will calculate the optimal alignment by dynamic programming.

목차

Abstract
 1. Introduction
  1.1. Background
  1.2. Our Result
 2. Dynamic Programming
  2.1. The Algorithm
  2.2. The Tool: BioConductor
  2.3. The Result
  2.4. Remarks
 3. Local Search Alignment
  3.1 The Algorithm
  3.2 The Tool: BLAST
  3.3 The Result
 4. Progressive Alignment
  4.1 The Algorithm
  4.2 The Tool: ClustalW
  4.3 The Result
 5. Online Tools Implementations
  5.1 MultiIdent
  5.2 EGM
  5.3 FASTA
  5.4 FFAS
 References

저자정보

  • Zhi-min Zhou Department of Computer Science Zhejiang Water Conservancy And Hydropower College, Hangzhou, China
  • Zhong-wen Chen Department of Computer Science Zhejiang Water Conservancy And Hydropower College, Hangzhou, China

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