원문정보
초록
영어
New mesoporous silica nanoparticle (MSNs) with high surface area and pore volume has been synthesized successfully using TritonX-100 as main and Tween 60 as co-template (at various concentrations). Ibuprofen a water insoluble model drug was loaded into the synthesized silica nanoparticle and studied for sustained release capability. All the as synthesized and drug loaded nanoparticle were characterized using physicochemical techniques such as FTIR, Difuse reflectance UV spectroscopy(UV-DRS), Brunauer Emmett Teller (BET) technique, Differential Scanning Calorimetri ( DSC ),Thermo gravimetric analysis (TGA), powder XRD and scanning electron microscopy( SEM) for the morphology and drug loading. From the results it was noted that all the silica nanoparticle synthesized by sol-gel method were mesoporous with high surface area and pore volume (1024.3, 1056.2 and 1083.6 m2 g-1 and 0.9229, 0.9904 and 0.8468 for TW6-1rt, TW6-2rt and TW6-3rt respectively) and have the capability of up taking 32 % ibuprofen model drug further they shows initial burst release for 50h followed by sustained maintenance of dose even after 150h.
목차
1. Introduction
2. Experimental
2.1. Materials
2.2. Synthesis of silica carrier
2.3. Loading of DX
2.4. Characterization
3. Results and discussions
3.1. Characterization
3.2. Drug inclusion in the particles
3.3. Dissolution studies
4. Conclusions
Acknowledgements
References