earticle

영어

Studies have proven the diagnostic efficiency of multiple markers for ovarian cancer diagnosis with in vitro diagnostic multivariate index assays. We compared the diagnostic performance of multiple marker combinations and carbohydrate antigen (CA) 125 alone, a widely utilized tumor marker, for early ovarian cancer detection. Overall, 257 serum samples from Korean women, including 204 patients with benign tumors and 53 patients with ovarian cancer, were analyzed. We used 22 serum markers showing specific reaction to ovarian cancer was the concentration value obtained from xMAP™ bead-based technology (Luminex Corp.). To identify markers that combined well with CA125, a multivariate model that comprised combinations of 2–3 marker, including CA125, was created, and the best marker combinations were selected by assessing area under the receiver-operating curves (AUCs). The AUC values of CA125 alone, CA125+M2, and CA125+M2+M4 were 69.96%, 76.63%, and 81.28%, respectively. It was confirmed that multiple marker combinations including CA125 showed better diagnostic performance than CA125 alone for early-stage ovarian cancer diagnosis.