원문정보
초록
영어
In the present study, we investigated the effect of swimming training and sudden detraining on learning ability and spatial memory capability and on neurogenesis and brain-derived neurotrophic factor (BDNF) expression in the hippocampus of mice. Male ICR mice were randomly assigned into three groups (n= 15 in each group): the control group, the swimming training group, and the detraining group. The mice in the swimming training group were made to swim (6 days/week, 60 min/day) for 8 weeks. The mice in the detraining group were accomplished the same swimming program for 4 weeks and then discontinued exercise for 4 weeks. In the present results, enhanced short-term and spatial learning memories and increased hippocampal neurogenesis and BDNF expression were observed in the mice of the swimming training group. In contrast, decreased short-term and spatial learning memories were observed in the mice of the swimming detraining group compared to the control level. Hippocampal neurogenesis and BDNF expression were also decreased in the mice of the detraining group near to the control level. Here in this study, we suggest that sudden cessation of exercise training might bring decline of the brain functions.
목차
INTRODUCTION
MATERIALS AND METHODS
Animals and treatments
Swimming training and detraining
Step-down avoidance test
Radial-arm maze test
Tissue preparation
Immunohistochemistry
Western blot analysis
Statistical analysis
RESULTS
Effect of training and detraining on step-down avoidance test
Effect of training and detraining on radial-arm maze test
Effect of training and detraining on the hippocampal neurogenesis
Effect of training and detraining on the BDNF protein expression
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES