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The purpose of this study is to determine whether the efficacy of considering handedness constraint-induced movement therapy (CIMT) affects the performance level of the activities of daily living (ADL) and hand function in a chronic traumatic brain injury patient. The design of this study was a case report. The subject was 18 years old and a right-sided hemiparesis. CIMT is the method of the intervention that limit the movement of unaffected upper limb. This experiment was performed by using a elbow splint in this subject which was applied more than 14-hr a day for 8 weeks. Assessments were performed three conditions: baseline is no intervention, First intervention performed for 4 weeks, and second intervention performed. First intervention was performed by participating common life task with the right hand. Intensive hand activity program was provided to subject during second intervention. The ability of the ADL performance was measured by Canadian occupational performance measure (COPM) and functional independence measure (FIM). For the measurement of hand function was Jebsen-Taylor hand function test and grip dynamometer. After the 8 weeks CIMT, the result of subject's performance level of ADL and hand function were enhanced. The FIM score increased by 102 points from 88 points after 8 weeks. During intervention first intervention, writing and simulated feeding sub-items measuring time were decreased by 29.05 sec, 20.05 sec from 35.01 sec, 38.03 sec in Jebsen hand function test, however, during second intervention , turning over cards, picking up large light object, picking up large weighted object sub-items measuring time were decreased by 13.01 sec, 7.07 sec, 11.01 sec from 18.04 sec, 10.05 sec, 15 sec. Grip strength increased on right hand nearly doubled from 11kg. These findings suggest that considering handedness while CIMT performed could influence the affected hand function and performance level of ADL. It provides a helpful information for further studied in this field.