원문정보
Antifungal Activities of Hemistepsin A and B Isolated from Hemistepita lyrata Bunge against Dandruff-causing Microbe Malassezia obutusa
초록
영어
There are a large number of bioactive sesquiterpene lactones from compositae plants including Hemistepita lyrata Bunge. In the present study, we purified two sesquiterpene lactones, Hemistepsin A and B, from H. lyrata and evaluated their antimicrobial activities against Malassezia obutusa. Chromatographic separation was used for the preparation of Hemistepsin A and B, and the identity of these compounds was confirmed by NMR. Strong inhibition of growth of M. obutusa was obtained with all doses of Hemistepsin A tested. Moreover, antifungal activity of Hemistepsin A occurred in a dose-dependent manner. Hemistepsin B also showed potent antifungal activity at the dose of 800 μm/disc. From these results, it was suggested that Hemistepsin A and B be beneficial for the preparation of the useful agent for treating scalp diseases occurred by dandruff-causing Malassezia species.
목차
1. 서론
2. 재료 및 방법
2.1. 식물체 재료
2.2. 미생물 배양
2.3. Compound A와 B의 분리
2.4. 항균활성 측정
3. 결과 및 고찰
3.1. Compound A(Hemistepsin A)의 구조 규명
3.2. Compound B(Hemistepsin B)의 구조 규명
3.3. Hemistepsin A와 B의 비듬균에 대한 항균활성
4. 결론
감사의 글
REFERENCES