원문정보
초록
영어
Recently, Theragnostic technology has been in the spotlight for the accurate treatment by guidance of diagnostic tools. Ultrasound, among the diagnostic method, has been applied widely due to the various advantages such as safety, inexpensive cost and real-time imaging. However, microbubbles as theragnostic agent have been limited for the encapsulation of drug. Herein, we developed humans serum albumin nanoparticles conjugated microbubbles for increase of stability and loading ratio of anti-cancer drug. and we investigated optimal resonance frequency to maximize activation of microbubbles that enhance the sensitivity of ultrasound imaging and local delivery of anti-cancer drugs. The human serum albumin nanoparticles conjugated microbubbles described size distribution of 1.1 ± 0.5 μm and optimal resonance frequency of 3MHz. And contrast of ultrasound imaging was strongly increased by narrow-distributed microbubbles activated optimal resonance frequency. In the investigation of cytotoxicity, microbubbles slightly lead to increase cellular penetration of drugs with exposure of optimal resonance frequency. Therefore, we expect this result should be progressive for the next generative technology of theragnosis.