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논문검색

Neuroblastoma cell culturing on the atomic functionalized diamond surface

원문정보

Hyo-Geun NAM, Hong-Gi OH, Dae-Ae JO, Hye-Bin PARK, Kwang-Hwan JHEE, Chang-Man KIM, Si-Hyung KIM, Dae-Hoon KIM, Min-Hye KIM, Kwang-soup SONG

한국생물공학회 한국생물공학회 학술대회 2013 춘계학술대회 2013.04 pp.299-299
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

The material with superior biocompatibility and physical-chemical stability is required to fabricate high sensitive biosensors and electrochemical sensors. The diamond thin film is an excellent material for biosensors and electrochemical sensors since it has high biocompatibility, physical- chemical stability, wide potential window (3.0~3.5V) and low background current.We culture the neuroblastoma cell (SH-SY5Y) on the surface of nanocrystalline diamond (NCD) and microcrystalline diamond (MCD) thin film. In this work, we functionalize the diamond surface with fluorine(-F), oxygen(-O) and amine(-NH2) groups by plasma and UV irradiation methods. And we evaluate the morphology and proliferation of neuroblastoma cell by the atomic function groups on the diamond surface. As a result, oxygen and amine groups are more suitable for cell culture than that of fluorine on the diamond surface. This result is considered from the difference of wettability. Oxygen and amine groups are hydrophilic and fluorine is a super hydrophobic. In addition, the NCD is higher cell viability than that of MCD. Based on these results, we will try to the cell patterning for single cell.

키워드

저자정보

  • Hyo-Geun NAM Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi 730-701.
  • Hong-Gi OH Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi 730-701.
  • Dae-Ae JO Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi 730-701.
  • Hye-Bin PARK Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi 730-701.
  • Kwang-Hwan JHEE Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi 730-701.
  • Chang-Man KIM Gumi Electronics &Information Technology Research Institute, Biomedical IT Convergence Center Gumi 730-853.
  • Si-Hyung KIM Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi 730-701.
  • Dae-Hoon KIM Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi 730-701.
  • Min-Hye KIM Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi 730-701.
  • Kwang-soup SONG Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi 730-701.

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자료제공 : 네이버학술정보

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