원문정보
초록
영어
Engineered muscle constructs may provide a promising perspective on the regeneration or substitution of irreversibly damaged or diseased muscle tissues. Recent advancedment in stem cell biology as enabled growth factor or soluble factor induced myogenic commitment or pluripotent stem cells. However, the highly ordered structured of native muscle tissue necessitates special consideration for guidance effect as well as cell-biomaterlas interactions favoring the myogenic commitment. Recently, graphene oxide (GO) has been utilized for bioactive substrates accounting for its unique electrical and chemical properties. GO may chemically modified to contained various functional groups. Furhtermore, modified GO results in tubanable hydrophobiticy and or chemical properties. In this study, we have immobilized GO for tunable electrical and chemical proerpties on the glass substrates or the micro-patterned substrates for providing defied guidance effect. Here, we demonstrate that GO substrates have profound effect the myogenic commitment of stem cells.