원문정보
초록
영어
The fission yeast Schizosaccharomyces pombe is an important model eukaryotic system with applications into, cell cycle regulation and as a platform for producing target chemicals. It has the smallest number of protein encoding genes in its genome, making it an ideal model for studying minimal cells. To further the study into this model organism, the genome-scale metabolic network was reconstructed and analyzed. Validation of the metabolic network was performed through comparison with fermentation data and the single gene mutant library. Through this analysis of the metabolic network, we attain a better understanding of its inner working and unique metabolic characteristics of S. pombe. [This work was supported by the Technology Development Program to Solve Climate Changes (systems metabolic engineering for biorefineries) from the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea (NRF-2012- C1AAA001-2012M1A2A2026556)]