원문정보
초록
영어
The yeast Kluyveromyces marxianus has been gaining importance in biotechnology due to several inherent characteristics that make it an attractive host for producing high valued compounds over its well characterized counterpart, Saccharomyces cerevisiae. It has the highest reported specific growth rate among the yeast species and as a Crabtree negative yeast, there is no concern with ethanol contamination in the presence of excess glucose. As with all yeast, it also possesses a high tolerance to low pH conditions, making it an ideal host for the production of organic acids. Here, the metabolic network of this yeast was employed to examine the production capacity to produce organic acids. [This work was supported by the Technology Development Program to Solve Climate Changes (systems metabolic engineering for biorefineries) from the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea (NRF- 2012-C1AAA001-2012M1A2A2026556)]