원문정보
초록
영어
The importance of Corynebacterium glutamicum as a production host is increasing due to its efficient production capacity of amino acids and organic acids. Its biotechnological value previously led to reconstruction of two versions of its genome-scale metabolic network models, but there still exist metabolic characteristics of this organism that need to be thoroughly investigated through systems biological framework. To this end, we reconstructed an updated version of C. glutamicum metabolic network model, namely CglMBEL, involving 304 genes with 552 reactions and 434 metabolites. Reconstruction of the CglMBEL and its simulation studies demonstrated herein provided new insights into the physiology of C. glutamicum. In particular, the model-driven studies are expected to serve as an effective framework for the characterization of other organisms of interest. [This work was supported by the Technology Development Program to Solve Climate Changes (systems metabolic engineering for biorefineries) from the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea (NRF-2012-C1AAA001-2012M1A2A2026556)]