원문정보
초록
영어
AKT protein family plays vital role in signal transduction by modification of substrate activity in regulation of metabolism, cell cycle progression, transcription, cell survival, motility, apoptosis, differentiation, angiogenesis and insulin responses. AKT protein family includes AKT1, AKT2 and AKT3 whereas AKT2 and AKT3 have one isomer each. In insulin signaling process, the insulin downstream action causes insulin receptor phosphorylation and subsequently insulin receptor substrate proteins formation. In the present study, we have performed phylogenetic analysis and conservation domain analysis for these AKT family members. We applied a pioneer and fast approach to study the structural, functional and phylogenetic relationship among the AKT family member. Our study shows a rapid way to calculate amino acid sequences in terms of evolutionary conservation rates and provides vital information about regions of structural and functional importance.