원문정보
초록
영어
Nanoparticles and hydrogels with designed physical and chemical properties can exhibit unique characteristics which have high potentials to overcome various problems in current clinical approaches to treat diseases. This presentation will introduce our recent study in the application of designed nanobiomaterials for therapeutic growth factor and cell delivery. Targeted delivery of gold nanoparticles conjugated with angiogenic growth factor to ischemic tissues resulted in recovery of blood perfusion through enhanced angiogenesis. Transplantation of designed alginate capsule-in-capsules containing pancreatic islets and nanoparticle contrast agents allowed immunoprotected insulin-producing cell delivery and multimodal imaging. Active ferrogels that can be remotely controlled by a magnetic field was fabricated to deliver various biological agents including anticancer drug, DNA, growth factor, and cells on demand.