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초록
영어
G-protein-coupled receptor (GPCR) superfamily is the largest known receptor family, characterized by seven transmembrane domains and considered to be an important drug target. In this study we focused on an orphan GPCR termed as GPR18. As there is no X-ray crystal structure has been reported for this receptor, we report on a homology model of GPR18. Template structure with high homology was used for modeling and ten models were developed. A model was selected and refined by energy minimization. The selected model was further validated using various parameters. Our results could be a starting point for further structure based drug design.
목차
Abstract
1. Introduction
2. Experimental Section
2.1. Sequence Analysis of GPR18
2.2. Homology Modeling of GPR18
3. Results and Discussion
3.1. Sequence Analysis of GPR18
3.2. Homology Modeling of GPR18
3.3. Discussions
4. Conclusion
References
1. Introduction
2. Experimental Section
2.1. Sequence Analysis of GPR18
2.2. Homology Modeling of GPR18
3. Results and Discussion
3.1. Sequence Analysis of GPR18
3.2. Homology Modeling of GPR18
3.3. Discussions
4. Conclusion
References
저자정보
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